More than a quarter of all Americans—and two out of three older Americans—are estimated to have at least two chronic physical or behavioral health problems. Treatment for people living with these multiple chronic conditions (MCC) currently accounts for an estimated 66 percent of the Nation's health care costs. As the U.S. population ages, the number of patients with MCC continues to grow. This mounting challenge has become a major public health issue that is linked to suboptimal health outcomes and rising health care costs.

In this video, Dr. Boustani provides an overview of methodological challenges of developing, testing, and implementing complex interventions for complex patients within diverse care settings and of possible solutions from complexity science, agile implementation, multilevel interventions, adaptive trials, rapid cycle evaluation methods, integrating quality improvement and implementation science, and mixed methods.